Wiskott–Aldrich syndrome

Also known as: eczema-thrombocytopenia-immunodeficiency syndrome; WAS

X-linked immunodeficiency with microthrombocytopenia and eczema.

Medical specialty: Hematology
Subspecialty: Hematology / Platelet disorders
Sex & age distribution: Male: affected, nearly all; Female: carriers; Children: yes, infancy
Gene(s) involved: WAS

Etiology & mechanism

WASP deficiency disrupts actin cytoskeleton in hematopoietic cells.

Gene(s) involved (1)

WAS

Symptoms & signs (7)

autoimmunitybleedingbloody diarrheaeczemalymphomamicrothrombocytopeniarecurrent infections

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