Vogt–Koyanagi–Harada syndrome

Also known as: VKH syndrome

Bilateral granulomatous panuveitis with neurologic and skin changes.

Medical specialty: Ophthalmology
Subspecialty: Ophthalmology / Uveitis
Sex & age distribution: Male: affected; Female: affected, female predominance; Children: yes, rare
Gene(s) involved: HLA-DRB1*04:05, IL17F, IL23R

Etiology & mechanism

T-cell autoimmunity against melanocytes.

Gene(s) involved (3)

HLA-DRB1*04:05IL17FIL23R

Symptoms & signs (8)

alopeciabilateral blurred visionexudative retinal detachmentheadachemeningismuspoliosistinnitusvitiligo

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.