Tumor-induced osteomalacia syndrome

Also known as: Oncogenic osteomalacia

Phosphate wasting osteomalacia from FGF23-secreting tumors.

Medical specialty: Rheumatology
Subspecialty: Rheumatology / Metabolic bone disease
Sex & age distribution: Male: affected; Female: affected; Children: rare
Gene(s) involved: FN1-FGFR1

Etiology & mechanism

Tumor FGF23 secretion.

Gene(s) involved (1)

FN1-FGFR1

Symptoms & signs (4)

bone painfractureshypophosphatemiamuscle weakness

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.