Stiff person syndrome

Also known as: Moersch–Woltman syndrome

Autoimmune stiffness and spasms.

Medical specialty: Rheumatology
Subspecialty: Rheumatology / Neuroimmunology
Sex & age distribution: Male: affected; Female: affected, 2:1; Children: rare
Gene(s) involved: HLA-DQB1*0201

Etiology & mechanism

Anti-GAD65 and anti-amphiphysin antibodies.

Gene(s) involved (1)

HLA-DQB1*0201

Symptoms & signs (5)

anxietyaxial stiffnesshyperlordosispainful spasmsstartle-induced spasms

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.