Richter syndrome

Also known as: Transformation of chronic lymphocytic leukemia

Transformation of CLL into aggressive lymphoma.

Medical specialty: Hematology
Subspecialty: Hematology / Lymphoproliferative disorders
Sex & age distribution: Male: affected; Female: affected; Children: no
Gene(s) involved: CDKN2A, NOTCH1, TP53

Etiology & mechanism

Clonal evolution.

Gene(s) involved (3)

CDKN2ANOTCH1TP53

Symptoms & signs (4)

feverhigh ldhrapid lymph node enlargementweight loss

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.