Restless legs syndrome

Also known as: Willis–Ekbom disease

Sensorimotor disorder with urge to move legs, worse at rest and evening.

Medical specialty: Neurology
Subspecialty: Neurology / Sleep medicine
Sex & age distribution: Male: affected; Female: more common (about 2:1); Children: yes, can start in childhood
Gene(s) involved: BTBD9, MAP2K5, MEIS1, PTPRD, SKOR1, TOX3

Etiology & mechanism

Brain iron deficiency and dopaminergic dysfunction.

Gene(s) involved (6)

BTBD9MAP2K5MEIS1PTPRDSKOR1TOX3

Symptoms & signs (5)

relief with movementsleep disruptionuncomfortable leg sensationsurge to move legsworse at rest and evening

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.