Premature ovarian insufficiency syndrome

Also known as: POI

Loss of ovarian function before age 40.

Medical specialty: Obstetrics and Gynecology
Subspecialty: Obstetrics and Gynecology / Reproductive medicine
Sex & age distribution: Male: not affected; Female: affected; Children: rare
Gene(s) involved: BMP15, FIGLA, FMR1, FOXL2, GDF9, MCM8, MCM9, NOBOX, NR5A1, STAG3

Etiology & mechanism

Follicle depletion or dysfunction.

Gene(s) involved (10)

BMP15FIGLAFMR1FOXL2GDF9MCM8MCM9NOBOXNR5A1STAG3

Symptoms & signs (5)

amenorrheahot flashesinfertilitylow estrogenvaginal dryness

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.