POEMS syndrome

Also known as: Crow–Fukase syndrome; Takatsuki syndrome

Paraneoplastic syndrome of polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes.

Medical specialty: Hematology
Subspecialty: Hematology / Plasma cell disorders
Sex & age distribution: Male: affected, slightly more; Female: affected; Children: no, onset 40–60
Gene(s) involved: None recorded

Etiology & mechanism

Overproduction of VEGF by plasma cells.

Gene(s) involved (0)

No gene recorded.

Symptoms & signs (8)

edemaendocrinopathymonoclonal plasma cell disorderorganomegalypapilledemapolyneuropathysclerotic bone lesionsskin changes

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.