Neuroleptic malignant syndrome

Also known as: NMS

Life-threatening reaction to dopamine antagonists.

Medical specialty: Psychiatry
Subspecialty: Psychiatry / Drug-induced syndromes
Sex & age distribution: Male: affected, male predominance; Female: affected; Children: yes
Gene(s) involved: CYP2D6, DRD2

Etiology & mechanism

Central dopamine blockade causing rigidity and hyperthermia.

Gene(s) involved (2)

CYP2D6DRD2

Symptoms & signs (5)

altered mental statusautonomic instabilityelevated creatine kinasehyperthermiamuscle rigidity

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.