Mitral valve prolapse

Also known as: Barlow syndrome; click-murmur syndrome; floppy mitral valve

Systolic displacement of mitral leaflets into the left atrium.

Medical specialty: Cardiology
Subspecialty: Cardiology / Valvular heart disease
Sex & age distribution: Male: affected; Female: affected, more common; Children: yes, adolescents
Gene(s) involved: DCHS1, DZIP1, FLNA, LMCD1, PLD1, TNS1

Etiology & mechanism

Myxomatous degeneration of the leaflets and chordae; familial forms.

Gene(s) involved (6)

DCHS1DZIP1FLNALMCD1PLD1TNS1

Symptoms & signs (8)

anxietyatypical chest paindyspneafatiguelate systolic murmurmid-systolic clickoften asymptomaticpalpitations

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.