Leukocyte adhesion deficiency syndrome

Also known as: LAD

Defective leukocyte adhesion with recurrent infections and delayed cord separation.

Medical specialty: Hematology
Subspecialty: Hematology / Bone marrow failure
Sex & age distribution: Male: affected; Female: affected equally; Children: yes, neonatal
Gene(s) involved: FERMT3, ITGB2, SLC35C1

Etiology & mechanism

Integrin beta-2 or fucosylation defects.

Gene(s) involved (3)

FERMT3ITGB2SLC35C1

Symptoms & signs (5)

delayed umbilical cord separationleukocytosisomphalitisperiodontitisrecurrent infections

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