Laron syndrome

Also known as: Growth hormone insensitivity

Severe short stature from growth hormone receptor deficiency.

Medical specialty: Endocrinology
Subspecialty: Endocrinology / Pediatric endocrinology
Sex & age distribution: Male: affected; Female: affected equally; Children: yes, infancy
Gene(s) involved: GHR, IGF1, IGFALS, STAT5B

Etiology & mechanism

Defective GH receptor signaling and low IGF-1.

Gene(s) involved (4)

GHRIGF1IGFALSSTAT5B

Symptoms & signs (8)

frontal bossinghigh growth hormonehypoglycemialow igf-1severe short staturesmall hands and feetsparse hairtruncal obesity

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.