Landau–Kleffner syndrome

Also known as: Acquired epileptic aphasia

Childhood syndrome of acquired aphasia with epileptiform EEG, especially in sleep.

Medical specialty: Neurology
Subspecialty: Neurology / Epilepsy; Pediatric neurology
Sex & age distribution: Male: more common (about 2:1); Female: affected; Children: yes, onset 3–8 years
Gene(s) involved: GRIN2A

Etiology & mechanism

Heterogeneous; GRIN2A variants in a subset.

Gene(s) involved (1)

GRIN2A

Symptoms & signs (5)

auditory agnosiabehavioral changeepileptiform eeg in sleeploss of acquired languageseizures (in many)

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