Immune effector cell-associated neurotoxicity syndrome

Also known as: ICANS

Neurotoxicity after CAR-T cell therapy.

Medical specialty: Oncology
Subspecialty: Oncology / Oncologic emergencies
Sex & age distribution: Male: affected; Female: affected; Children: yes
Gene(s) involved: None recorded

Etiology & mechanism

Endothelial activation and cytokine-mediated blood-brain barrier disruption.

Gene(s) involved (0)

No gene recorded.

Symptoms & signs (6)

aphasiacerebral edemaconfusiondecreased consciousnessseizurestremor

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.