Hereditary spastic paraplegia type 23

Also known as: Lison syndrome; SPG23

Recessive HSP with pigmentary skin changes.

Medical specialty: Neurology
Subspecialty: Neurology / Movement disorders
Sex & age distribution: Male: affected; Female: affected equally; Children: yes, onset in childhood
Gene(s) involved: DSTYK

Etiology & mechanism

Linked to 1q24-q32; a DSTYK variant reported.

Gene(s) involved (1)

DSTYK

Symptoms & signs (3)

premature grayingspastic paraparesisvitiligo

Note

Gene evidence limited; verify

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.