Hereditary diffuse gastric cancer syndrome

Also known as: HDGC

Germline CDH1 mutations causing diffuse gastric and lobular breast cancer.

Medical specialty: Oncology
Subspecialty: Oncology / Hereditary cancer syndromes
Sex & age distribution: Male: affected; Female: affected, with lobular breast cancer; Children: rare
Gene(s) involved: CDH1, CTNNA1

Etiology & mechanism

E-cadherin loss.

Gene(s) involved (2)

CDH1CTNNA1

Symptoms & signs (5)

diffuse gastric cancerdysphagialobular breast cancersignet ring cellsweight loss

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