Hereditary breast and ovarian cancer syndrome

Also known as: HBOC syndrome

BRCA-related predisposition to breast, ovarian, prostate and pancreatic cancer.

Medical specialty: Oncology
Subspecialty: Oncology / Hereditary cancer syndromes
Sex & age distribution: Male: affected, prostate, breast and pancreatic cancer; Female: affected, breast and ovarian cancer; Children: rare
Gene(s) involved: BARD1, BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D

Etiology & mechanism

Germline homologous recombination repair deficiency.

Gene(s) involved (7)

BARD1BRCA1BRCA2BRIP1PALB2RAD51CRAD51D

Symptoms & signs (5)

early breast cancermale breast cancerovarian cancerpancreatic cancerprostate cancer

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.