Hemolytic uremic syndrome

Also known as: HUS

Triad of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury.

Medical specialty: Nephrology
Subspecialty: Nephrology / Thrombotic microangiopathies
Sex & age distribution: Male: affected; Female: affected equally; Children: yes, typical HUS commonly in children under 5
Gene(s) involved: C3, CFB, CFH, CFHR1, CFI, DGKE, MCP, THBD

Etiology & mechanism

Shiga toxin-producing E. coli endothelial injury or complement dysregulation (atypical HUS).

Gene(s) involved (8)

C3CFBCFHCFHR1CFIDGKEMCPTHBD

Symptoms & signs (9)

anuriabloody diarrheaedemahemolytic anemiahypertensionoliguriapallorseizuresthrombocytopenia

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.