Goodpasture syndrome

Also known as: Anti-GBM disease

Pulmonary hemorrhage with rapidly progressive glomerulonephritis from anti-glomerular basement membrane antibodies.

Medical specialty: Nephrology
Subspecialty: Nephrology / Glomerular diseases
Sex & age distribution: Male: affected, young men; Female: affected, older women; Children: rare
Gene(s) involved: HLA-DRB1*15:01

Etiology & mechanism

Autoantibodies to the alpha-3 chain of type IV collagen.

Gene(s) involved (1)

HLA-DRB1*15:01

Symptoms & signs (7)

anemiadyspneafeverhematuriahemoptysisoliguriarapidly rising creatinine

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.