Complex regional pain syndrome

Also known as: Reflex sympathetic dystrophy

Disproportionate limb pain after injury with autonomic changes.

Medical specialty: Rheumatology
Subspecialty: Rheumatology / Soft tissue disorders
Sex & age distribution: Male: affected; Female: affected, 3:1; Children: yes, adolescent girls
Gene(s) involved: HLA-B62, HLA-DQ

Etiology & mechanism

Neuroinflammation and sensitization.

Gene(s) involved (2)

HLA-B62HLA-DQ

Symptoms & signs (6)

allodyniaburning painskin color changesstiffnessswellingtemperature changes

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.