Castleman syndrome

Also known as: Angiofollicular lymph node hyperplasia

Lymphoproliferative disorder with HHV-8 or idiopathic multicentric forms.

Medical specialty: Oncology
Subspecialty: Oncology / Hematologic malignancies
Sex & age distribution: Male: affected; Female: affected; Children: rare
Gene(s) involved: IL6, TRAF3

Etiology & mechanism

IL-6 overproduction.

Gene(s) involved (2)

IL6TRAF3

Symptoms & signs (6)

cytopeniasedemafatiguefeverlymphadenopathynight sweats

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.