Antisynthetase syndrome

Also known as: Anti-Jo-1 syndrome

Myositis, interstitial lung disease, arthritis and mechanic's hands with antisynthetase antibodies.

Medical specialty: Rheumatology
Subspecialty: Rheumatology / Inflammatory myopathies
Sex & age distribution: Male: affected; Female: affected, more common; Children: rare
Gene(s) involved: HLA-DRB1*03

Etiology & mechanism

Anti-tRNA synthetase autoimmunity.

Gene(s) involved (1)

HLA-DRB1*03

Symptoms & signs (6)

arthritisfeverinterstitial lung diseasemechanic's handsmyositisraynaud phenomenon

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