4p16.3 deletion with Greek warrior helmet face.
- Specialty
- Pediatrics
- Subspecialty
- Pediatrics / Pediatric genetics
- Sex & age distribution
- Male: affected; Female: affected, 2:1 female predominance; Children: yes, from birth
- Gene(s) involved
- LETM1, NSD2
- Alternative names & eponyms
- 4p deletion syndrome
Etiology & mechanism
Contiguous deletion including WHSC1 and LETM1.
Gene(s) involved (2)
Symptoms & signs (6)
In plain terms, someone with Wolf–Hirschhorn syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
3 shared
Edwards syndrome
growth restriction, heart defects, intellectual disability
3 shared
Mowat–Wilson syndrome
heart defects, intellectual disability, seizures
2 shared
Apert syndrome
cleft palate, intellectual disability
2 shared
Borjeson–Forssman–Lehmann syndrome
intellectual disability, seizures
2 shared
Cardiofaciocutaneous syndrome
intellectual disability, seizures
2 shared
Cornelia de Lange syndrome
heart defects, intellectual disability
2 shared
Crigler–Najjar syndrome
intellectual disability, seizures
2 shared
EAST syndrome
intellectual disability, seizures
2 shared
Emanuel syndrome
cleft palate, heart defects
2 shared
Fetal alcohol syndrome
growth restriction, intellectual disability
Shares genes with
None.
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