X-linked overgrowth with embryonal tumor risk.
- Specialty
- Nephrology
- Subspecialty
- Nephrology / Renal oncology
- Sex & age distribution
- Male: affected; Female: carriers mild; Children: yes
- Gene(s) involved
- GPC3, GPC4, OFD1
- Alternative names & eponyms
- SGBS
Etiology & mechanism
GPC3 variants.
Gene(s) involved (3)
Symptoms & signs (7)
In plain terms, someone with Simpson–Golabi–Behmel syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
2 shared
Beckwith–Wiedemann syndrome
macroglossia, macrosomia
2 shared
Orofaciodigital syndrome type 1
cleft palate, polydactyly
2 shared
Perlman syndrome
macrosomia, wilms tumor
1 shared
Aniridia-Wilms tumor-genitourinary anomalies-retardation syndrome
wilms tumor
1 shared
Apert syndrome
cleft palate
1 shared
Bamforth–Lazarus syndrome
cleft palate
1 shared
Barakat syndrome
renal dysplasia
1 shared
Bardet–Biedl syndrome
polydactyly
1 shared
Branchio-oto-renal syndrome
renal dysplasia
1 shared
Cantú syndrome
macrosomia
Shares genes with
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