Endocrinology · Endocrinology / Reproductive endocrinology
Androgen insensitivity syndrome
also: AIS; Morris syndrome; testicular feminization syndrome
X-linked disorder of sex development with end-organ resistance to androgens in 46,XY individuals.
- Specialty
- Endocrinology
- Subspecialty
- Endocrinology / Reproductive endocrinology
- Sex & age distribution
- Male: affected (46,XY); Female: carriers; phenotypic females with complete form; Children: yes, presents as inguinal hernia in infancy or primary amenorrhea at puberty
- Gene(s) involved
- AR
- Alternative names & eponyms
- AIS; Morris syndrome; testicular feminization syndrome
Etiology & mechanism
Loss of androgen receptor function prevents virilization.
Gene(s) involved (1)
Symptoms & signs (8)
In plain terms, someone with Androgen insensitivity syndrome may experience the following — click any to explore related syndromes:
Same gene(s)
Other syndromes that involve one of this syndrome's genes.
Overlapping symptoms
Other syndromes that share symptoms with this one.
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Shares symptoms with
2 shared
Mayer–Rokitansky–Küster–Hauser syndrome
absent uterus, primary amenorrhea
2 shared
Perrault syndrome
infertility, primary amenorrhea
1 shared
Asherman syndrome
infertility
1 shared
Bloom syndrome
infertility
1 shared
Chiari–Frommel syndrome
infertility
1 shared
Frasier syndrome
primary amenorrhea
1 shared
Hyperprolactinemia–galactorrhea syndrome
infertility
1 shared
Kallmann syndrome
primary amenorrhea
1 shared
Kartagener syndrome
infertility
1 shared
Klinefelter syndrome
infertility
Shares genes with
None.
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