Zollinger–Ellison syndrome

Also known as: Gastrinoma syndrome

Gastrin-secreting tumor causing severe peptic ulcer disease.

Medical specialty: Endocrinology
Subspecialty: Endocrinology / Neuroendocrine tumors
Sex & age distribution: Male: affected, slightly more common; Female: affected; Children: rare
Gene(s) involved: MEN1

Etiology & mechanism

Gastrinoma in pancreas or duodenum, 25% MEN1.

Gene(s) involved (1)

MEN1

Symptoms & signs (6)

bleedingdiarrheaepigastric painrecurrent peptic ulcersrefluxweight loss

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.