Yellow nail syndrome

Also known as: Yellow nail-lymphedema syndrome

Yellow nails, lymphedema and pleural effusions.

Medical specialty: Pulmonology
Subspecialty: Pulmonology / Pleural disease
Sex & age distribution: Male: affected; Female: affected, equal; Children: rare, onset after age 40
Gene(s) involved: FOXC2

Etiology & mechanism

Lymphatic vessel dysfunction.

Gene(s) involved (1)

FOXC2

Symptoms & signs (6)

bronchiectasischronic coughchronic pleural effusionlymphedemasinusitisyellow thickened nails

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.