Wolff–Parkinson–White syndrome

Also known as: Kent bundle pre-excitation; WPW

Ventricular pre-excitation through an accessory atrioventricular pathway with paroxysmal supraventricular tachycardia.

Medical specialty: Cardiology
Subspecialty: Cardiology / Cardiac electrophysiology
Sex & age distribution: Male: affected, slightly more common; Female: affected; Children: yes, presents in infancy or childhood
Gene(s) involved: GATA4, NKX2-5, PRKAG2, TBX5

Etiology & mechanism

Accessory pathway allows reentry circuits and rapid conduction during atrial fibrillation.

Gene(s) involved (4)

GATA4NKX2-5PRKAG2TBX5

Symptoms & signs (7)

chest discomfortdelta wave on ecgdizzinesspalpitationssudden death (rare)sudden rapid regular tachycardiasyncope

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.