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Syndrome reference sheet
Generated 13 Oct 2026
Endocrinology · Endocrinology / Adrenal disorders

Waterhouse–Friderichsen syndrome

Also known as: Acute adrenal hemorrhage in meningococcemia

Acute adrenal failure with purpura from bilateral adrenal hemorrhage in septicemia.

Medical specialty
Endocrinology
Subspecialty
Endocrinology / Adrenal disorders
Sex & age distribution
Male: affected; Female: affected; Children: yes, more common in children
Gene(s) involved
None recorded

Etiology & mechanism

Overwhelming infection with disseminated intravascular coagulation.

Gene(s) involved (0)

No gene recorded.

Symptoms & signs (7)

adrenal crisiscollapsedisseminated intravascular coagulationfeverhypotensionpurpurashock
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