Uncombable hair syndrome

Also known as: Pili trianguli et canaliculi; Spun glass hair syndrome

Dry, frizzy hair that cannot be combed flat.

Medical specialty: Dermatology
Subspecialty: Dermatology / Hair disorders
Sex & age distribution: Male: affected; Female: affected, slight female predominance; Children: yes, onset in infancy to early childhood
Gene(s) involved: PADI3, TCHH, TGM3

Etiology & mechanism

Abnormal inner root sheath keratinization.

Gene(s) involved (3)

PADI3TCHHTGM3

Symptoms & signs (4)

dry hairsilvery blonde hairtriangular hair cross-sectionunruly hair

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.