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Syndrome reference sheet
Generated 13 Oct 2026
Cardiology · Cardiology / Cardiac electrophysiology

Twiddler syndrome

Also known as: Pacemaker twiddler syndrome

Device manipulation causing lead dislodgement.

Medical specialty
Cardiology
Subspecialty
Cardiology / Cardiac electrophysiology
Sex & age distribution
Male: affected; Female: affected, more common; Children: rare
Gene(s) involved
None recorded

Etiology & mechanism

Rotation of the pulse generator in its pocket.

Gene(s) involved (0)

No gene recorded.

Symptoms & signs (5)

diaphragmatic stimulationhiccupsloss of pacingpocket painsyncope
SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.