Toxic shock syndrome

Also known as: TSS

Superantigen-mediated shock from Staphylococcus aureus or Streptococcus pyogenes.

Medical specialty: Pediatrics
Subspecialty: Pediatrics / Pediatric infectious disease
Sex & age distribution: Male: affected; Female: affected, menstrual cases; Children: yes
Gene(s) involved: HLA-DQB1*06:02, HLA-DRB1*15:01

Etiology & mechanism

Superantigen toxin T-cell activation.

Gene(s) involved (2)

HLA-DQB1*06:02HLA-DRB1*15:01

Symptoms & signs (6)

desquamationdiffuse rashfeverhypotensionmultiorgan failurevomiting

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.