TNF receptor-associated periodic syndrome

Also known as: familial Hibernian fever; TRAPS

Prolonged episodes of fever, myalgia and migratory rash.

Medical specialty: Rheumatology
Subspecialty: Rheumatology / Autoinflammatory disease
Sex & age distribution: Male: affected; Female: affected equally; Children: yes, childhood onset
Gene(s) involved: TNFRSF1A

Etiology & mechanism

TNFRSF1A variants impair receptor shedding and cause ER stress.

Gene(s) involved (1)

TNFRSF1A

Symptoms & signs (6)

abdominal painamyloidosisconjunctivitismigratory myalgiaperiorbital edemaprolonged fever for 1–3 weeks

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.