Thunderclap headache syndrome

Also known as: Thunderclap headache

Sudden severe headache peaking within one minute.

Medical specialty: Neurology
Subspecialty: Neurology / Headache medicine; Vascular neurology
Sex & age distribution: Male: affected; Female: affected, more common; Children: yes, rare
Gene(s) involved: ATP1A2, CACNA1A, SCN1A

Etiology & mechanism

Subarachnoid hemorrhage, RCVS, dissection, CVT or primary.

Gene(s) involved (3)

ATP1A2CACNA1ASCN1A

Symptoms & signs (3)

peak within a minutesevere explosive headacheurgent hemorrhage exclusion

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.