Temple syndrome

Also known as: Maternal UPD14 syndrome

Imprinting disorder with growth restriction and early puberty.

Medical specialty: Endocrinology
Subspecialty: Endocrinology / Pediatric endocrinology
Sex & age distribution: Male: affected; Female: affected equally; Children: yes
Gene(s) involved: DLK1, MEG3

Etiology & mechanism

Maternal UPD14 or paternal deletion.

Gene(s) involved (2)

DLK1MEG3

Symptoms & signs (6)

early pubertyfeeding problemshypotoniashort staturesmall for gestational agetruncal obesity

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.