Sweet syndrome

Also known as: Acute febrile neutrophilic dermatosis

Painful plaques with fever and neutrophilia.

Medical specialty: Dermatology
Subspecialty: Dermatology / Neutrophilic dermatoses
Sex & age distribution: Male: affected; Female: affected, classic form 3–4 times more common; Children: yes, rare
Gene(s) involved: MEFV

Etiology & mechanism

Cytokine dysregulation with neutrophil infiltration; associated with infection, malignancy and drugs.

Gene(s) involved (1)

MEFV

Symptoms & signs (6)

arthralgiaconjunctivitisfevermalaiseneutrophiliapainful erythematous plaques

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.