Shone syndrome

Also known as: Shone complex

Multilevel left-sided obstructive lesions: supramitral ring, parachute mitral valve, subaortic stenosis, coarctation.

Medical specialty: Cardiology
Subspecialty: Cardiology / Congenital heart disease
Sex & age distribution: Male: affected; Female: affected equally; Children: yes, infancy
Gene(s) involved: MYH6, NOTCH1

Etiology & mechanism

Abnormal left heart development.

Gene(s) involved (2)

MYH6NOTCH1

Symptoms & signs (6)

failure to thriveheart failuremurmurpoor feedingtachypneaweak femoral pulses

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.