Serotonin syndrome

Also known as: Serotonin toxicity

Excess serotonergic activity from drug combinations.

Medical specialty: Psychiatry
Subspecialty: Psychiatry / Drug-induced syndromes
Sex & age distribution: Male: affected; Female: affected; Children: yes, after overdose
Gene(s) involved: CYP2D6

Etiology & mechanism

Overstimulation of 5-HT1A and 5-HT2A receptors.

Gene(s) involved (1)

CYP2D6

Symptoms & signs (8)

agitationclonusdiaphoresisdiarrheahyperreflexiahyperthermiatachycardiatremor

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.