Schnitzler syndrome

Also known as: Chronic urticaria with monoclonal IgM

Autoinflammatory syndrome with chronic urticaria and IgM gammopathy.

Medical specialty: Hematology
Subspecialty: Hematology / Plasma cell disorders
Sex & age distribution: Male: affected; Female: affected; Children: no
Gene(s) involved: NLRP3

Etiology & mechanism

IL-1 overproduction.

Gene(s) involved (1)

NLRP3

Symptoms & signs (6)

arthralgiabone painchronic urticariafeverigm paraproteinlymphadenopathy

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.