SAPHO syndrome

Also known as: Synovitis, acne, pustulosis, hyperostosis, osteitis

Chronic inflammatory osteoarticular and skin disorder.

Medical specialty: Rheumatology
Subspecialty: Rheumatology / Autoinflammatory disease
Sex & age distribution: Male: affected; Female: affected, slightly more common; Children: yes
Gene(s) involved: LPIN2, PSTPIP2

Etiology & mechanism

Autoinflammatory process, possible low-grade infection.

Gene(s) involved (2)

LPIN2PSTPIP2

Symptoms & signs (5)

anterior chest wall painpalmoplantar pustulosissevere acnesternoclavicular hyperostosissynovitis

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.