Postural orthostatic tachycardia syndrome

Also known as: POTS

Excessive heart rate rise on standing without orthostatic hypotension, with chronic orthostatic symptoms.

Medical specialty: Cardiology
Subspecialty: Cardiology / Autonomic cardiology
Sex & age distribution: Male: affected, less often; Female: affected, 4–5 times more common; Children: yes, adolescents
Gene(s) involved: SLC6A2

Etiology & mechanism

Heterogeneous: hypovolemia, hyperadrenergic state, autonomic neuropathy, autoimmunity or deconditioning.

Gene(s) involved (1)

SLC6A2

Symptoms & signs (11)

blurred visionbrain fogexercise intolerancefatigueheadachelightheadedness on standingnauseapalpitationssleep disturbancesyncopetremulousness

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.