Polycystic ovary syndrome

Also known as: PCOS; Stein–Leventhal syndrome

Hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology.

Medical specialty: Endocrinology
Subspecialty: Endocrinology / Reproductive endocrinology
Sex & age distribution: Male: not applicable; Female: affected only; Children: yes, adolescents; also premature adrenarche in girls
Gene(s) involved: DENND1A, ERBB4, FBN3, FSHR, INSR, LHCGR, THADA, YAP1

Etiology & mechanism

Insulin resistance, increased LH pulsatility and ovarian androgen excess; polygenic.

Gene(s) involved (8)

DENND1AERBB4FBN3FSHRINSRLHCGRTHADAYAP1

Symptoms & signs (10)

acanthosis nigricansacneamenorrheahirsutisminfertilityinsulin resistanceirregular mensesobesitypolycystic ovariesscalp hair loss

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