Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome

Also known as: PFAPA syndrome

Recurrent fever in young children.

Medical specialty: Rheumatology
Subspecialty: Rheumatology / Autoinflammatory disease
Sex & age distribution: Male: affected, slightly more; Female: affected; Children: yes, before age 5
Gene(s) involved: None recorded

Etiology & mechanism

Dysregulated innate immunity.

Gene(s) involved (0)

No gene recorded.

Symptoms & signs (4)

aphthous ulcerscervical adenitisfever every 3–6 weekspharyngitis

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.