Obstructive sleep apnea syndrome

Also known as: OSA

Recurrent upper airway collapse during sleep.

Medical specialty: Pulmonology
Subspecialty: Pulmonology / Sleep and breathing disorders
Sex & age distribution: Male: affected, 2–3:1 male predominance; Female: affected, rises after menopause; Children: yes, adenotonsillar hypertrophy
Gene(s) involved: GNAS, PTGER3

Etiology & mechanism

Anatomic narrowing with reduced pharyngeal muscle tone.

Gene(s) involved (2)

GNASPTGER3

Symptoms & signs (6)

daytime sleepinesshypertensionloud snoringmorning headachenocturiawitnessed apneas

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.