Nelson syndrome

Also known as: Post-adrenalectomy pituitary tumor progression

Rapidly enlarging corticotroph adenoma after bilateral adrenalectomy for Cushing disease.

Medical specialty: Endocrinology
Subspecialty: Endocrinology / Pituitary disorders
Sex & age distribution: Male: affected; Female: affected; Children: rare
Gene(s) involved: USP8

Etiology & mechanism

Loss of cortisol negative feedback.

Gene(s) involved (1)

USP8

Symptoms & signs (5)

cranial nerve palsieselevated acthheadachehyperpigmentationvisual field defects

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.