Muir–Torre syndrome

Also known as: Torre syndrome

Sebaceous skin tumors with visceral malignancy.

Medical specialty: Dermatology
Subspecialty: Dermatology / Genodermatoses
Sex & age distribution: Male: affected; Female: affected, slight male predominance; Children: rare
Gene(s) involved: MLH1, MSH2, MSH6, PMS2

Etiology & mechanism

Mismatch repair deficiency causing microsatellite instability.

Gene(s) involved (4)

MLH1MSH2MSH6PMS2

Symptoms & signs (5)

colorectal cancergenitourinary cancerkeratoacanthomassebaceous adenomassebaceous carcinoma

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.