Michelis–Castrillo syndrome

Also known as: FHHNC

Severe renal magnesium and calcium wasting with progressive renal failure.

Medical specialty: Nephrology
Subspecialty: Nephrology / Tubular disorders
Sex & age distribution: Male: affected; Female: affected; Children: yes, childhood
Gene(s) involved: CLDN16, CLDN19

Etiology & mechanism

Paracellin-1 (claudin-16) or claudin-19 defect.

Gene(s) involved (2)

CLDN16CLDN19

Symptoms & signs (6)

kidney stonesnephrocalcinosisocular defects (cldn19)polyuriaprogressive renal failureurinary tract infection

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