Möbius syndrome

Also known as: Moebius syndrome

Congenital facial and abducens nerve palsies.

Medical specialty: Ophthalmology
Subspecialty: Ophthalmology / Strabismus and neuro-ophthalmology
Sex & age distribution: Male: affected; Female: affected, equal; Children: yes, congenital
Gene(s) involved: PLXND1, REV3L

Etiology & mechanism

Brainstem developmental disruption of cranial nerves VI and VII.

Gene(s) involved (2)

PLXND1REV3L

Symptoms & signs (6)

esotropiafacial paralysisfeeding difficultyinability to abductlimb anomaliesspeech delay

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.