Lambert–Eaton myasthenic syndrome

Also known as: LEMS

Paraneoplastic neuromuscular disorder, often with small cell lung cancer.

Medical specialty: Oncology
Subspecialty: Oncology / Paraneoplastic syndromes
Sex & age distribution: Male: affected; Female: affected; Children: rare
Gene(s) involved: CACNA1A

Etiology & mechanism

Antibodies to presynaptic voltage-gated calcium channels.

Gene(s) involved (1)

CACNA1A

Symptoms & signs (5)

areflexiaautonomic dysfunctiondry mouthfatigueproximal weakness

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.