Kartagener syndrome

Also known as: Primary ciliary dyskinesia with situs inversus

Primary ciliary dyskinesia with dextrocardia, sinusitis and bronchiectasis.

Medical specialty: Cardiology
Subspecialty: Cardiology / Congenital heart disease
Sex & age distribution: Male: affected; Female: affected; Children: yes, neonatal respiratory distress
Gene(s) involved: CCDC39, CCDC40, DNAH11, DNAH5, DNAI1, RSPH4A, RSPH9

Etiology & mechanism

Defective ciliary motility.

Gene(s) involved (7)

CCDC39CCDC40DNAH11DNAH5DNAI1RSPH4ARSPH9

Symptoms & signs (7)

bronchiectasischronic coughchronic sinusitisdextrocardiainfertilityrecurrent otitis mediasitus inversus

SyndromeScope — educational reference. Content is model-generated and not clinically verified; always confirm against OMIM, Orphanet and GeneReviews before clinical use.